• The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer 

      Meltzer, Sebastian; Kristensen, Annette Torgunrud; Abrahamsson, Hanna Josefine; Solbakken, Arne Mide; Flatmark, Kjersti; Dueland, Svein; Bakke, Kine Mari; Bousquet, Paula; Negård, Anne; Johansen, Christin; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)
      Background In colorectal cancer, the inflamed tumour microenvironment with its angiogenic activities is immune- tolerant and incites progression to liver metastasis. We hypothesised that angiogenic and inflammatory factors ...
    • Markers of mitochondrial metabolism in tumor hypoxia, systemic inflammation, and adverse outcome of rectal cancer 

      Bousquet, Paula; Meltzer, Sebastian; Sønstevold, Linda; Esbensen, Qin Ying; Dueland, Svein; Flatmark, Kjersti; Sitter, Beathe; Bathen, Tone Frost; Seierstad, Therese; Redalen, Kathrine; Eide, Lars; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and ...
    • Next-generation sequencing reveals mitogenome diversity in plasma extracellular vesicles from colorectal cancer patients 

      Bjørnetrø, Tonje; Bousquet, Paula; Redalen, Kathrine Røe; Siebke, Anne-Marie; Lüders, Torben; Stang, Espen; Sanabria-Moreno, Adriana Maria; Johansen, Christin; Fuglestad, Anniken Jørlo; Kersten, Christian; Meltzer, Sebastian; Ree, Anne Hansen (Peer reviewed; Journal article, 2023)
      Background Recent reports have demonstrated that the entire mitochondrial genome can be secreted in extracellular vesicles (EVs), but the biological attributes of this cell-free mitochondrial DNA (mtDNA) remain ...
    • Sex disparities in vitamin D status and the impact on systemic inflammation and survival in rectal cancer 

      Abrahamsson, Hanna Josefine; Meltzer, Sebastian; Hagen, Vidar Nyløkken; Johansen, Christin; Bousquet, Paula; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)
      Background We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating ...